Under the following conditions:
- Google Chrome set as the default browser.
- Microsoft Outlook running in "Windows XP" compatibility mode.
Clicking on links inside emails (or any hyperlink even inside contacts), Google Chrome will open up in a blank "Untitled" tab. UI menus and the ominibox are completely unresponsive.
Turns out, running Microsoft Outlook in "Windows XP" compatibility mode will cause Google Chrome to fail to open links in Outlook.
So, disable "compatibility mode" and all should be well.
Hope that helps,